regulation of cell cycle progression by plk3
| PAG Title | regulation of cell cycle progression by plk3 |
| PAG ID | WAG000006 |
| Type | P |
| Source Link |  BioCarta |
| Publication Reference | NA |
| PAG Description | The focus of this pathway is to illustrate the role of Polo-like Kise 3 (Plk3 also known as Prk and Fnk) as part of the regulatory cascade leading to apoptosis and the arrest cell cycle progression prior to M phase. Phosphorlyation of Cdc25C on serine-216 causes the arrest of the cell cycle at the G2/M phase border by preventing Cdc25C from activating cyclinB1/Cdk1. Xie et al. demonstrated that Plk3 like Chk1 and Chk2 also phosphorlyates Cdc25C on serine-216 contributing to cell cycle arrest. Additiolly they found that Plk3 also phosphorylates p53 on serine 20 at step that is stimulatory in the process leading up to p53-mediated apoptosis. |
| Species | Homo sapiens |
| nCoCo Score | 1,913 |
| Base PAG ID | WAG000006 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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